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[Regional features of sensitization of children to some noninfectious allergens]

I R Iuldashev1, V M Berzhets, O I Iusupova

  • 1Pediatric Medical Institute, Tashkent, Uzbekistan, Mechnikov Research Institute for Vaccines and Sera, Moscow, Russia.

Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|July 31, 2003
PubMed

Insights

This study found 6.0% of urban children have noninfectious allergies, impacting their quality of life. Key risk factors include family history and early-life feeding practices.

Area of Science:

  • Pediatric Allergy
  • Epidemiology
  • Environmental Health

Background:

  • Allergic diseases are a significant public health concern in childhood.
  • Understanding allergen sensitization patterns in urban environments is crucial.

Purpose of the Study:

  • To investigate the prevalence and characteristics of noninfectious allergen sensitization in urban children.
  • To identify specific features of sensitization to regional allergens.
  • To explore the clinical manifestations and risk factors associated with childhood allergies.

Main Methods:

  • Epidemiological investigation using the International Study of Asthma and Allergies in Childhood (ISAAC) program.
  • Analysis of sensitization to insect, pollen, and medicinal allergens in a cohort of 2,870 children.
  • Assessment of clinical symptoms, gastrointestinal and central nervous system involvement, and quality of life.

Main Results:

  • 6.0% (172 out of 2,870) of children exhibited sensitization to noninfectious allergens.
  • Prevalence rates ranged from 10.4 to 28.2 per 1000 urban children.
  • Identified specific sensitization patterns to regional allergens and a high prevalence of gastrointestinal and central nervous system symptoms.
  • Risk factors included hereditary predisposition, allergic diathesis, focal infections, and artificial feeding.

Conclusions:

  • Urban children show significant sensitization to common noninfectious allergens.
  • Allergic diseases in children present with diverse symptoms affecting daily life and academic performance.
  • Early identification of risk factors is vital for managing and preventing childhood allergies.

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