Related Experiment Video

Updated: Aug 15, 2026

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation
10:01

Development of Obliterative Bronchiolitis in a Murine Model of Orthotopic Lung Transplantation

Published on: July 10, 2012

[Bacterial infectious process in patients with chronic obliterating bronchiolitis]

M E Faustova1, E V Boĭtsova, A V Bogdanova

  • 1Research Institute of Pulmonology, Pavlov State Medical University, St. Petersburg, Russia.

Zhurnal Mikrobiologii, Epidemiologii I Immunobiologii
|July 31, 2003
PubMed

Insights

Chronic obliterating bronchiolitis in children involves inflammation caused by Streptococcus pneumoniae and Haemophilus influenzae. Haemophilus influenzae significantly worsens the disease severity and bronchial obstruction during exacerbations.

Area of Science:

  • Pediatric Pulmonology
  • Infectious Diseases
  • Microbiology

Background:

  • Chronic obliterating bronchiolitis in children is a serious condition.
  • It involves a chronic inflammatory and infectious process.
  • Streptococcus pneumoniae and Haemophilus influenzae are key pathogens.

Purpose of the Study:

  • To elucidate the role of Streptococcus pneumoniae and Haemophilus influenzae in pediatric chronic obliterating bronchiolitis.
  • To determine the specific contribution of Haemophilus influenzae to disease severity and bronchial obstruction.

Main Methods:

  • Analysis of causative agents in children with chronic obliterating bronchiolitis.
  • Assessment of pathogen detection rates during exacerbations.
  • Correlation of pathogen presence with the severity of bronchial obstruction.

Main Results:

  • Streptococcus pneumoniae and Haemophilus influenzae are the primary infectious agents.
  • Haemophilus influenzae plays a critical role in determining disease severity.
  • A high detection rate of H. influenzae correlates with pronounced bronchial obstruction during exacerbations.

Conclusions:

  • Both S. pneumoniae and H. influenzae initiate and sustain the inflammatory process.
  • H. influenzae is the main determinant of clinical severity in pediatric obliterating bronchiolitis.
  • Targeting H. influenzae may be crucial for managing severe cases and improving outcomes.

More Related Videos

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice15:43

Long Term Chronic Pseudomonas aeruginosa Airway Infection in Mice

Published on: March 17, 2014

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation06:15

Murine Intrapulmonary Tracheal Transplantation: A Model for Investigating Obliterative Airway Disease After Lung Transplantation

Published on: November 10, 2023

Related Concept Videos

Pneumonia I: Introduction01:30

Pneumonia I: Introduction

Pneumonia is an acute respiratory infection that targets the lungs, specifically the alveoli. These tiny air sacs, essential for oxygen exchange, become engorged with pus and fluid, severely hindering breathing, decreasing oxygen absorption, and causing significant pain and discomfort during respiration.
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Chronic Obstructive Pulmonary Disease-II: Pathophysiology01:20

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.01:25

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:
Chronic Obstructive Pulmonary Disease I: Introduction01:23

Chronic Obstructive Pulmonary Disease I: Introduction

Chronic obstructive pulmonary disease is a common, preventable, and treatable respiratory disorder characterized by persistent symptoms and progressive airflow limitation. This limitation results from a combination of small-airway disease (obstructive bronchiolitis) and parenchymal destruction (emphysema), both driven by chronic inflammation from exposure to harmful particles or gases.The disease includes two main pathological entities: emphysema, marked by destruction of alveolar walls and...
Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features01:24

Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features

Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...
Pneumonia I: Introduction01:29

Pneumonia I: Introduction

Pneumonia is an infection of the lower respiratory tract that leads to inflammation of the lung parenchyma, often resulting in the accumulation of inflammatory exudate in the alveoli and airways. Unlike the watery, low-protein fluid exudate in pulmonary edema, the exudate in this case is a thick fluid rich in immune cells, proteins, and debris produced during infection and inflammation.This impairs gas exchange and can lead to consolidation of lung tissue. The infection may be caused by a...