Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Six interaction profiles for simple mixtures.

Hana R Pohl1, Nickolette Roney, Sharon Wilbur

  • 1Agency for Toxic Substances and Disease Registry, US Department of Health and Human Services, 1600 Clifton Road, Atlanta, Georgia 30333, USA. hpohl@cdc.gov

Chemosphere
|August 2, 2003
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Worker studies suggest unique liver carcinogenicity potential of polyvinyl chloride microplastics.

American journal of industrial medicine·2023
Same author

Evaluation of ATSDR's MRL and EPA's RfCs/RfDs: Similarities, Differences, and Rationales.

Journal of toxicology and pharmacology·2023
Same author

Windows of sensitivity to toxic chemicals in the development of reproductive effects: an analysis of ATSDR's toxicological profile database.

International journal of environmental health research·2018
Same author

Historical View on Lead: Guidelines and Regulations.

Metal ions in life sciences·2017
Same author

Dataset for human sensitivity to chemicals during development of motor function.

Data in brief·2016
Same author

Windows of sensitivity to toxic chemicals in the motor effects development.

Regulatory toxicology and pharmacology : RTP·2015
Same journal

Tolerance of larval and juvenile tambaqui (Colossoma macropomum) to nitrogenous compounds.

Chemosphere·2026
Same journal

Reactivity and environmental fate of emerging contaminants in wastewater treatment systems: A reactive continuum framework approach.

Chemosphere·2026
Same journal

Vinasse fertigation modifies soil-microbiota-plant interactions and metabolism in sugarcane.

Chemosphere·2026
Same journal

Corrigendum to 'Exposure to the Polychlorinated biphenyl mixture Aroclor 1254 elicits neurological and cardiac developmental effects in early life stage zebrafish (Danio rerio)' [Chemosphere 371 (2025), 144023].

Chemosphere·2026
Same journal

Microplastic footprints in freshwater ecosystems: Raman spectroscopy of microplastics as indicator of anthropopressure in Northeastern Poland's lakes.

Chemosphere·2026
Same journal

Estimation of VOC emissions from an electric vehicle interior as a function of cabin air temperature using a selected ion tube flow mass spectrometer (SIFT-MS) measurement.

Chemosphere·2026
See all related articles

The Agency for Toxic Substances and Disease Registry (ATSDR) developed guidance and profiles for assessing chemical mixtures' toxicity and health risks. Methods include weight-of-evidence and pharmacokinetic modeling for environmental contaminants and hazardous waste site chemicals.

Area of Science:

  • Environmental Health Sciences
  • Toxicology
  • Computational Methods

Background:

  • Chemical mixtures pose complex health risks.
  • ATSDR researches mixture toxicity and risk assessment.
  • Innovative computational methods are needed for mixture analysis.

Purpose of the Study:

  • To provide guidance for health risk assessment of chemical mixtures.
  • To develop interaction profiles for common chemical mixtures.
  • To advance methods for evaluating joint toxic action.

Main Methods:

  • Development of a "Guidance Manual for the Assessment of Joint Toxic Action of Chemical Mixtures".
  • Creation of six interaction profiles for specific chemical mixtures (persistent organic pollutants, metals, volatile organic chemicals).

Related Experiment Videos

  • Application of weight-of-evidence methodology and physiologically based pharmacokinetic modeling.

    • Main Results:

    • Profiles address mixtures like chlorinated dioxins, PCBs, methyl mercury, common metals (lead, arsenic, cadmium), and VOCs (BTEX).
    • Weight-of-evidence approach used for most mixture assessments.
    • Physiologically based pharmacokinetic modeling applied to BTEX mixtures.

    Conclusions:

    • ATSDR provides resources for chemical mixture risk assessment.
    • Recommended approach for noncancer health hazards involves a target-organ toxicity dose modification of the hazard index.
    • Guidance and profiles aid in understanding and managing risks from complex chemical exposures.