Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

When is intervention warranted?

R D Williams1, D G Bostwick, C W Boone

  • 1Department of Urology, University of Iowa College of Medicine, Iowa City 52242-1089.

Journal of Cellular Biochemistry. Supplement
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Can breast cancer be prevented?

Annals of Saudi medicine·2007
Same author

High grade prostatic intraepithelial neoplasia with squamous differentiation.

Journal of clinical pathology·2006
Same author

Basal cell hyperplasia and basal cell carcinoma of the prostate: a comprehensive review and discussion of a case with c-erbB-2 expression.

Journal of clinical pathology·2005
Same author

Prostate intraepithelial neoplasia in Noble rats, a potential intermediate endpoint for chemoprevention studies.

European journal of cancer (Oxford, England : 1990)·2004
Same author

Classification and grading of the non-invasive urothelial neoplasms: recent advances and controversies.

Journal of clinical pathology·2003
Same author

Prostatic intraepithelial neoplasia.

Current urology reports·2002
Same journal

Understanding immune cell trafficking patterns via in vivo bioluminescence imaging.

Journal of cellular biochemistry. Supplement·2003
Same journal

In vivo molecular imaging.

Journal of cellular biochemistry. Supplement·2003
Same journal

Introduction to the physics of molecular imaging with radioactive tracers in small animals.

Journal of cellular biochemistry. Supplement·2003
Same journal

Can small animal imaging accelerate drug development?

Journal of cellular biochemistry. Supplement·2003
Same journal

Advances in molecular labeling, high throughput imaging and machine intelligence portend powerful functional cellular biochemistry tools.

Journal of cellular biochemistry. Supplement·2003
Same journal

Grappling with metastatic risk: bringing molecular imaging of Met expression toward clinical use.

Journal of cellular biochemistry. Supplement·2003
See all related articles

Designing a prostate cancer chemoprevention trial is challenging due to limited knowledge. Focusing on high-risk men without current disease offers a promising approach for future prevention studies.

Area of Science:

  • Oncology
  • Urology
  • Preventive Medicine

Background:

  • Prostate cancer chemoprevention trials face significant challenges.
  • Insufficient knowledge exists regarding drug interactions, biomarkers, and natural history for comprehensive risk stratification.
  • Current understanding limits the ability to effectively target all at-risk populations.

Purpose of the Study:

  • To propose a viable strategy for conducting prostate cancer chemoprevention trials.
  • To identify the most promising patient group for initial chemoprevention studies.
  • To explore the utility of short-term pilot studies for biomarker assessment.

Main Methods:

  • Suggests a placebo-controlled, prospective, and randomized study design.
  • Identifies men with a high probability of developing prostate cancer but no current disease (Group I) as the primary study cohort.

Related Experiment Videos

  • Recommends short-term pilot studies of "chemo-active" agents before surgical removal to assess biomarkers.

    • Main Results:

    • The study focuses on the feasibility and design of chemoprevention trials rather than presenting empirical results.
    • Pilot studies could yield valuable data on morphologic and other biomarkers.
    • Such studies may inform future research directions for preventing prostate cancer progression.

    Conclusions:

    • Chemoprevention trials in prostate cancer are complex but potentially highly beneficial.
    • Targeting high-risk individuals without current disease is a strategic starting point.
    • Pilot biomarker studies can provide crucial rationale for larger, future prevention efforts.