Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Biologic treatment for intervertebral disc degeneration: summary statement.

Frank M Phillips, Howard An, James D Kang

    Spine
    |August 5, 2003
    PubMed
    Summary

    Researchers are exploring growth factors and gene therapy to reverse intervertebral disc degeneration by restoring matrix components. These biological strategies show promise for halting or slowing this common condition.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Instrumented vs Non-Instrumented Fusion for Elderly Patients with Lumbar Spondylotic Conditions: A Causal Inference Analysis.

    Spine·2026
    Same author

    Feasibility and Early Safety of Single-Position Lateral Lumbar Interbody Fusion With Posterior Pedicle Screw Instrumentation and Fusion at the Ambulatory Surgery Center: A Preliminary Case Series.

    International journal of spine surgery·2026
    Same author

    Analysis of United States Federal Government Projections on Anticipated Shortages in the Orthopedic Surgeon Workforce.

    Orthopedics·2026
    Same author

    Early Clinical Safety Profile and Accuracy of Augmented Reality-Assisted Pedicle Screw Placement: A Multi-Center Analysis of 200 Screws.

    Clinical spine surgery·2026
    Same author

    Racial and Ethnic Minorities Are Underrepresented Among Studies Informing North American Spine Society Appropriate Use Criteria for Degenerative Spine Conditions.

    Global spine journal·2025
    Same author

    The Association Between Academic Promotion and Lifetime Salary Compensation in Orthopaedic Surgery.

    The Journal of the American Academy of Orthopaedic Surgeons·2025

    Area of Science:

    • Biomedical Engineering
    • Regenerative Medicine
    • Spinal Research

    Background:

    • Intervertebral disc degeneration (IDD) has historically been studied biomechanically.
    • Recent research focuses on the biological mechanisms underlying IDD.
    • Current understanding highlights decreased matrix components as a hallmark of degeneration.

    Purpose of the Study:

    • To investigate the potential of biological interventions to address intervertebral disc degeneration.
    • To explore the use of growth factors and gene therapy for disc regeneration.
    • To assess the feasibility of manipulating disc biology to reverse degenerative changes.

    Main Methods:

    • Review of preliminary studies on growth factor application.
    • Analysis of gene therapy techniques for disc matrix restoration.

    Related Experiment Videos

  • Evaluation of strategies targeting disc cellular and matrix components.

    • Main Results:

    • Preliminary studies demonstrate the efficacy of growth factors in replenishing disc matrix.
    • Gene therapy approaches show potential for restoring essential matrix components.
    • These biological strategies can counteract key molecular changes in disc degeneration.

    Conclusions:

    • Direct application of growth factors and gene therapy offer promising avenues to halt or slow intervertebral disc degeneration.
    • Restoring essential matrix components is a viable therapeutic goal.
    • Further research into these biological manipulation techniques is warranted for clinical translation.