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Moonlighting proteins: old proteins learning new tricks.

Constance J Jeffery1

  • 1Laboratory for Molecular Biology, MC567, Department of Biological Sciences, University of Illinois at Chicago, Chicago, IL 60607, USA. cjeffrey@uic.edu

Trends in Genetics : TIG
|August 7, 2003
PubMed
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Researchers discovered that newly identified proteins involved in replication, transcription, and tumor suppression often have multiple, previously known functions. This highlights the prevalence and significance of moonlighting proteins in biological systems.

Area of Science:

  • Molecular Biology
  • Biochemistry
  • Genetics

Background:

  • Proteins are fundamental to cellular processes, including DNA replication, transcription, and tumor suppression.
  • The discovery of proteins with multiple functions, known as moonlighting proteins, challenges traditional views of protein specificity.
  • Recent findings indicate that proteins identified in specific cellular roles may possess additional, uncharacterized functions.

Purpose of the Study:

  • To document and analyze recent discoveries of proteins exhibiting multiple functions.
  • To expand the known repertoire of moonlighting proteins.
  • To underscore the biological significance of protein moonlighting.

Main Methods:

  • Literature review of recent proteomic and functional studies.

Related Experiment Videos

  • Analysis of protein identification and characterization data across different laboratories.
  • Comparative analysis of protein functions in various cellular contexts.

    • Main Results:

    • Several newly identified proteins involved in replication, transcription, and tumor suppression were found to have pre-existing, documented functions.
    • These findings increase the number of known moonlighting proteins.
    • The study confirms that protein moonlighting is a common phenomenon.

    Conclusions:

    • The discovery of multiple functions in newly identified proteins reinforces the concept of protein moonlighting.
    • Understanding moonlighting proteins is crucial for a comprehensive view of cellular mechanisms.
    • These findings emphasize the adaptability and complexity of protein roles in organisms.