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[Relationship between body composition and bone mineral density in healthy premenopausal women]
Jian-min Liu1, Hong-yan Zhao, Guang Ning
1Department of Endocrinology, Rui-jin Hospital, Shanghai Second Medical University, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai 200025, China. ljmhh@public7.sta.net.cn
Objective:
To investigate the relative contribution of fat mass and lean mass on bone mineral density (BMD) in premenopausal healthy women.
Methods:
The BMD at lumbar spine, proximal femur and total body, together with fat mass and lean mass was determined by dual-energy X-ray absorptiometry (DEXA), the body height, weight, waist, and hip circumference were also measured, and body mass index (BMI) and waist-hip ratio were calculated in 282 premenopausal women.
Results:
Fat mass was a major determinant for BMI, BMI and lean mass were positively related with L2-4, proximal femur and total body BMD (P = 0.000 for all), and lean mass were the only independent factor contributing to L2-4 (standardized coefficient beta = 0.282, P = 0.000), proximal femur (beta = 0.336, P = 0.000) and total body BMD (beta = 0.361, P = 0.000) in stepwise regression analysis. The relationship between BMI and BMD was further improved after controlling fat mass, while decreased or even lost when controlling lean mass.
Conclusions:
Lean mass was an important factor determining BMD in premenopausal women.