Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

NMR Spectroscopy of Benzene Derivatives01:37

NMR Spectroscopy of Benzene Derivatives

11.7K
Simple unsubstituted benzene has six aromatic protons, all chemically equivalent. Therefore, benzene exhibits only a singlet peak at δ 7.3 ppm in the 1H NMR spectrum. The observed shift is far downfield because the aromatic ring current strongly deshields the protons. Any substitution on the benzene ring makes the aromatic protons nonequivalent, and the protons split each other. The peak is, therefore, no longer a singlet and the splitting pattern and their associated coupling...
11.7K
Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene01:13

Electrophilic Aromatic Substitution: Fluorination and Iodination of Benzene

7.7K
Bromination and chlorination of aromatic rings by electrophilic aromatic substitution reactions are easily achieved, but fluorination and iodination are difficult to achieve. Fluorine is so reactive that its reaction with benzene is difficult to control, resulting in poor yields of monofluoroaromatic products. To address this, Selectfluor reagent is used as a fluorine source in which a fluorine atom is bonded to a positively charged nitrogen.
7.7K
Cholinergic Antagonists: Chemistry and Structure-Activity Relationship01:29

Cholinergic Antagonists: Chemistry and Structure-Activity Relationship

2.9K
Cholinergic antagonists bind to cholinergic receptors and limit the effects of acetylcholine and other cholinergic agonists. Based on the specific cholinergic receptor affinity, these antagonists are classified as muscarinic or nicotinic. Anticholinergics interrupt parasympathetic innervations while sympathetic innervations remain uninterrupted. Muscarinic antagonists are also called 'muscarinic antagonists', 'antimuscarinics', or 'parasympatholytics'. Nicotinic...
2.9K
Radical Chain-Growth Polymerization: Overview01:10

Radical Chain-Growth Polymerization: Overview

3.6K
Chain-growth or addition polymerization is successive addition reactions of monomers with a polymer chain. In radical chain-growth polymerization, the reaction proceeds via a free-radical intermediate. The free radical is formed from radical initiators, which spontaneously generate free radicals by homolytic fission. Organic peroxides (such as dibenzoyl peroxide, as shown in Figure 1) or azo compounds are popular radical initiators. A low concentration ratio of radical initiator to monomer is...
3.6K
Oxidation of Phenols to Quinones01:17

Oxidation of Phenols to Quinones

5.0K
In the presence of oxidizing agents, phenols are oxidized to quinones. Quinones can be easily reduced back to phenols using mild reducing agents. The electron-donating hydroxyl group enhances the reactivity of the aromatic ring, enabling oxidation of the ring even in the absence of an α hydrogen.
o-hydroxy phenols are oxidized to o-quinones and p-hydroxy phenols to p-quinones. Such redox reactions involve the transfer of two electrons and two protons. The reversible redox...
5.0K
Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene01:15

Electrophilic Aromatic Substitution: Chlorination and Bromination of Benzene

12.1K
Chlorination and bromination are important classes of electrophilic aromatic substitutions, where benzene reacts with chlorine or bromine in the presence of a Lewis acid catalyst to give halogenated substitution products. A Lewis acid such as aluminium chloride or ferric chloride catalyzes the chlorination, and ferric bromide catalyzes the bromination reactions. During the bromination of alkenes, bromine polarizes and becomes electrophilic. However, in the bromination of benzene, the bromine...
12.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Fluorinated pesticides are a growing source of PFAS contamination in the environment: An Australian perspective on use, fate and ecotoxicity.

Ecotoxicology and environmental safety·2026
Same author

Anion Effects on the Structural and Magnetic Properties of a Series of Trinuclear Cu<sup>II</sup>-Ln<sup>III</sup>-Cu<sup>II</sup> Complexes.

ACS omega·2025
Same author

Methods for Untargeted Analysis of Milk Metabolites: Influence of Extraction Method and Optimization of Separation.

Metabolites·2025
Same author

Electrical Conductivity, Thermo-Mechanical Properties, and Cytotoxicity of Poly(3,4-Ethylenedioxythiophene):Poly(Styrene Sulfonate) (PEDOT:PSS)/Sulfonated Polyurethane Blends.

Materials (Basel, Switzerland)·2024
Same author

[Fe(µ<sub>2</sub>-OH)<sub>6</sub>]<sup>3-</sup> Linked Fe<sub>3</sub>O Triads: Mössbauer Evidence for Trigonal µ<sub>3</sub>-O<sup>2-</sup> or µ<sub>3</sub>-OH<sup>-</sup> Groups in Bridged versus Unbridged Complexes.

Molecules (Basel, Switzerland)·2024
Same author

Self-Assembly of four Ni<sub>16</sub> Molecular Wheels with Capsule and Tubular Supramolecular Architectures.

Chemistry, an Asian journal·2024
Same journal

Intermolecular C-H···O, Cl···Cl and π-π interactions in the 2-dichloromethyl derivative of vitamin K3.

Acta crystallographica. Section C, Crystal structure communications·2013
Same journal

Isolation, pharmacological activity and structure determination of physalin B and 5β,6β-epoxyphysalin B isolated from Congolese Physalis angulata L.

Acta crystallographica. Section C, Crystal structure communications·2013
Same journal

Transannular S···N interactions in 10-ethynyl-10H-phenothiazine 5-oxide and 5,5-dioxide.

Acta crystallographica. Section C, Crystal structure communications·2013
Same journal

Two polymorphs of 2-ethyl-3-hydroxy-6-methylpyridinium hydrogen N-acetyl-L-glutamate from powder diffraction data.

Acta crystallographica. Section C, Crystal structure communications·2013
Same journal

Three-dimensional hydrogen-bonded assembly in 2,2'-disulfanylidene-5,5'-biimidazolidinylidene-4,4'-dione-dimethylformamide-water (3/2/4).

Acta crystallographica. Section C, Crystal structure communications·2013
Same journal

Head-to-tail square-shaped cyclic hydrogen bonds leading to dimeric aggregates: 1,8-dibenzoyl-2,7-dihydroxynaphthalene and a comparison with its analogous benzoylnaphthalene.

Acta crystallographica. Section C, Crystal structure communications·2013
See all related articles

Related Experiment Video

Updated: Feb 28, 2026

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
05:59

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Published on: September 27, 2024

2.5K

7-Bromoquinolin-8-ol.

Gavin E Collis1, Anthony K Burrell, Kevin D John

  • 1Chemistry - Structural, Inorganic and Catalysis, Los Alamos National Laboratory, MS J514, Los Alamos, NM 87545, USA.

Acta Crystallographica. Section C, Crystal Structure Communications
|August 12, 2003
PubMed
Summary
This summary is machine-generated.

Bromination of an 8-hydroxyquinoline derivative occurred at the 7-position, forming hydrogen-bonded dimers in the solid state. This structural analysis reveals key insights into the compound's molecular arrangement and intermolecular interactions.

More Related Videos

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
08:31

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

Published on: October 11, 2019

11.1K
Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

12.4K

Related Experiment Videos

Last Updated: Feb 28, 2026

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds
05:59

Author Spotlight: Advancing Antimicrobial Resistance Research with Innovative Approaches and Synthetic Compounds

Published on: September 27, 2024

2.5K
Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine
08:31

Optimized Griess Reaction for UV-Vis and Naked-eye Determination of Anti-malarial Primaquine

Published on: October 11, 2019

11.1K
Facile Preparation of 4-Substituted Quinazoline Derivatives
11:51

Facile Preparation of 4-Substituted Quinazoline Derivatives

Published on: February 15, 2016

12.4K

Area of Science:

  • Organic Chemistry
  • Crystallography
  • Molecular Structure

Background:

  • 8-Hydroxyquinoline derivatives are important scaffolds in medicinal chemistry.
  • Understanding the structural impact of halogenation is crucial for designing new compounds.

Purpose of the Study:

  • To determine the precise structure of a brominated 8-hydroxyquinoline derivative.
  • To investigate the intermolecular interactions and solid-state packing.

Main Methods:

  • Single-crystal X-ray diffraction analysis was performed.
  • Structural elucidation of the compound C(9)H(6)BrNO.

Main Results:

  • Bromination occurred regioselectively at the 7-position of the 8-hydroxyquinoline ring.
  • The crystal structure revealed the presence of intermolecular O-H...N hydrogen bonds.
  • These interactions lead to the formation of hydrogen-bonded dimers in the solid state.
  • Weak intramolecular O-H...N hydrogen bonds were also observed.

Conclusions:

  • The study precisely defines the structure of the 7-bromo-8-hydroxyquinoline derivative.
  • Intermolecular hydrogen bonding dictates the dimeric packing in the solid state.
  • This structural information is valuable for predicting the properties and reactivity of related compounds.