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SV40 in human brain cancers and non-Hodgkin's lymphoma

Regis A Vilchez1, Janet S Butel

  • 1Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA.

Oncogene
|August 12, 2003
PubMed

Insights

Simian virus 40 (SV40) DNA and its proteins are linked to human brain cancers and non-Hodgkin's lymphoma (NHL). Further research is needed to confirm SV40's role in causing these diseases.

Area of Science:

  • Oncology
  • Virology
  • Molecular Biology

Background:

  • Simian virus 40 (SV40) is a DNA tumor virus known to cause brain cancers and lymphomas in animals.
  • SV40 oncogenesis involves the viral large tumor antigen (T-ag) inactivating tumor-suppressor proteins p53 and pRb.
  • Recent studies suggest a significant association between SV40 markers and human brain cancers and non-Hodgkin's lymphoma (NHL).

Purpose of the Study:

  • To review molecular, pathological, and clinical data linking SV40 to human brain cancers and NHL.
  • To discuss the potential etiologic role of SV40 in these malignancies.
  • To identify future research directions for SV40's role in human cancer.

Main Methods:

  • Review of independent molecular biology studies.
  • Systematic assessment of existing data on SV40 and human tumors.
  • Analysis of viral DNA, T-ag, and other viral markers in cancer tissues.

Main Results:

  • SV40 DNA, T-ag, or other viral markers have been detected in primary human brain cancers.
  • A significant association exists between SV40 and human brain tumors.
  • SV40 T-ag DNA is significantly associated with human non-Hodgkin's lymphoma (NHL).

Conclusions:

  • SV40 is implicated in the pathogenesis of primary human brain cancers and NHL.
  • Evidence suggests SV40 may be a human pathogen.
  • Further research is required to establish a definitive etiologic role for SV40 in human malignancies.
Keywords:
Non-programmatic

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