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Updated: Sep 20, 2026

Nasal Potential Difference to Quantify Trans-epithelial Ion Transport in Mice
Published on: July 4, 2018
[Expressions of chloride channel ClC-2 and ClC-3 in human nasal polyps]
Objective:
To investigate the role of chloride channel ClC-2 and ClC-3 in human nasal polyps.
Method:
Two chloride channels ClC-2 and ClC-3 were studied in 27 cases of nasal polyps with immunochemistric staining.
Result:
Nasal polyps revealed strong positive staining of ClC-2 and ClC-3, the ClC-2 and ClC-3 proteins localized mainly in epithelial cells, sub-epithelial mucous glands without significant distinction. The number of positive cells of ClC-2 and ClC-3 are 17.6 +/- 6.33 and 23.49 +/- 6.14.
Conclusion:
The chloride channels ClC-2 and ClC-3 may play a role in the formation of nasal polyps.
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