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Asymmetric autocatalysis induced by chiral hydrocarbon [2.2]paracyclophanes
Itaru Sato1, Atsushi Ohno, Yohei Aoyama
1Department of Applied Chemistry, Faculty of Science, Tokyo University of Science, Kagurazaka, Shinjuku-ku, Tokyo, 162-8601, Japan.
Organic & Biomolecular Chemistry
|August 22, 2003
Abstract:
Chiral hydrocarbon [2.2]paracyclophanes act as chiral initiators in asymmetric autocatalysis in the addition of diisopropylzinc to pyrimidine-5-carbaldehyde and give highly enantiomerically enriched 5-pyrimidyl alkanol with a reversed sense of the enantioselectivity to that of other [2.2]paracyclophanes with heteroatoms.