Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Mapping tumor vascular diversity by screening phage display libraries.

Amado J Zurita1, Wadih Arap, Renata Pasqualini

  • 1The University of Texas M.D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|August 23, 2003
PubMed
Summary

Identifying novel proteins on tumor vasculature using in vivo phage display is key for developing targeted cancer diagnostics and therapeutics. This approach maps tumor microvasculature for improved treatment strategies.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeting arginine metabolism overcomes chemotherapy resistance in aggressive-variant prostate cancers.

iScience·2026
Same author

Brain shuttle peptides derived from phage display.

Advances in pharmacology (San Diego, Calif.)·2026
Same author

Premature termination of early-phase cancer clinical trials: "It's the economy, stupid!"

Journal of the National Cancer Institute·2026
Same author

An emerging family of immunogenic epitopes in Chagas disease.

Trends in parasitology·2026
Same author

A Phase 2, Randomized, Controlled Trial of Best Systemic Therapy Versus Best Systemic Therapy with Definitive Treatment of the Primary Tumor in Metastatic Prostate Cancer.

European urology·2026
Same author

Decoding and deciphering a subcellular ZIP code system.

Trends in cell biology·2026

Area of Science:

  • Oncology
  • Vascular Biology
  • Biotechnology

Background:

  • Tumor vasculature exhibits structural and molecular diversity, offering potential for targeted therapies.
  • Novel proteins on tumor blood vessels can be identified using advanced techniques.

Purpose of the Study:

  • To explore the use of in vivo phage display for identifying tumor vasculature targets.
  • To develop strategies for selective and effective targeting of tumor vessels for diagnostics and therapeutics.

Main Methods:

  • In vivo phage display screening to select peptides targeting tumor vasculature.
  • Identification of ligand-receptor pairs and their cellular distribution.
  • Complementary imaging studies for functional characterization of tumor angiogenesis.

Related Experiment Videos

Main Results:

  • Selection of various peptides targeting normal tissues, cancer, and angiogenesis-related diseases.
  • Identification of receptors for the selected peptides.
  • Advancement in understanding tumor blood vessel abnormalities during progression.

Conclusions:

  • In vivo phage display is effective in identifying tumor vasculature targets.
  • Development of a ligand-receptor map of human cancer microvasculature is feasible.
  • Clinical applications for targeted cancer diagnostics and therapeutics are anticipated.