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Morphological and cytochemical characteristics of leukaemic promyelocytes
1Department of Haematology, University of Bari-Medical School, Policlinico, Piazza G. Cesare 11, Bari 70124, Italy.
Best Practice & Research. Clinical Haematology
|August 26, 2003
Abstract:
Evaluation of cell morphology is usually sufficient to diagnose acute promyelocytic leukaemia (APL). In this chapter we discuss the features of classical hypergranular APL, the APL variant, hyperbasophilic promyelocytic leukaemia, APL with basophil-like granules, acute eosinophilic leukaemia with PML/RARalpha positivity and the morphology of APL cells lacking t(15;17). In addition to morphological examination, cytochemical investigations (peroxidase chloroacetate-esterase, etc.) may help further in defining the cytology of leukaemic cells in APL.