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Effect of baseline vasodilation on adrenergic reactions of systemic hemodynamics
L I Osadchii1, T V Balueva, I V Sergeev
1Laboratory of Blood Circulation Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg. tch@infran.ru
Bulletin of Experimental Biology and Medicine
|August 26, 2003
Abstract:
Systemic vasodilation produced by sodium nitroprusside in various concentrations and accompanied by a decrease in baseline blood pressure was followed by progressive reduction in pressor responses to alpha-adrenoceptor agonist phenylephrine (mesatone) in rats. In a blood pressure range of below the physiological level (80-100 mm Hg), a positive linear correlation was revealed between the decrease in baseline blood pressure and pressor effect of phenylephrine.