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What do knockout models teach us about the enteric nervous system?

C I Hagl1, S Holland-Cunz, K-H Schäfer

  • 1Department of Paediatric Surgery, Clinical Hospital Mannheim, University Heidelberg, Theodor-Kutzer-Ufer 1-3, 68135 Mannheim, Germany. cornelia.hagl@kch.ma.uni-heidelberg.de

European Journal of Pediatric Surgery : Official Journal of Austrian Association of Pediatric Surgery ... [Et Al] = Zeitschrift Fur Kinderchirurgie
|August 27, 2003
PubMed
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Basic fibroblast growth factor (FGF) and growth hormone (GH) impact enteric nervous system (ENS) development. While their absence causes morphological abnormalities, these effects are not life-threatening, suggesting compensatory mechanisms in ENS formation.

Area of Science:

  • Developmental biology
  • Neuroscience
  • Genetics

Background:

  • Enteric nervous system (ENS) formation involves complex genetic and cellular processes.
  • Neural crest cell migration, differentiation, and survival are crucial for ENS development.
  • Previous studies identified various mutations affecting ENS development, offering insights into its complexity.

Purpose of the Study:

  • To investigate the role of basic fibroblast growth factor (FGF) and growth hormone (GH) in ENS development.
  • To determine the impact of FGF and GH deficiency on the morphology of the enteric nervous system.

Main Methods:

  • Analysis of morphological abnormalities in the enteric nervous system of knockout models lacking FGF or GH.
  • Comparative study of ENS development in the absence of specific growth factors.

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Main Results:

  • A lack of basic fibroblast growth factor (FGF) or growth hormone (GH) resulted in morphological abnormalities of the enteric nervous system.
  • These defects were not severe enough to be life-threatening, indicating potential compensatory mechanisms.

Conclusions:

  • FGF and GH play a role in ENS development, influencing neuronal morphology.
  • The limited impact of FGF and GH deficiency suggests that other growth factors may compensate for their absence in ENS formation.