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Related Experiment Videos

Selection on coding regions determined Hox7 genes evolution.

Mario Ali Fares1, Daniela Bezemer, Andrés Moya

  • 1Departamento de Genética, Univesidad de Valencia, Valencia, Spain.

Molecular Biology and Evolution
|September 2, 2003
PubMed
Summary
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Hox7 genes evolved under varying selection pressures, with positive selection after duplications driving functional divergence in specific protein regions. This highlights the interplay of positive and negative selection in shaping vertebrate evolution.

Area of Science:

  • Evolutionary developmental biology
  • Comparative genomics
  • Vertebrate evolution

Background:

  • Hox genes are crucial for vertebrate body plan regionalization and morphological evolution.
  • Gene duplication and loss result in variable Hox gene numbers across vertebrate lineages.
  • Evolutionary pressures governing Hox gene conservation and loss remain largely unclear.

Purpose of the Study:

  • To investigate the evolutionary forces acting on Hox7 genes in different vertebrate lineages.
  • To identify instances of positive selection and functional divergence in Hox7 gene evolution.

Main Methods:

  • Comparative analysis of Hox7 gene sequences across various vertebrate lineages.
  • Phylogenetic analyses to detect gene duplication events.

Related Experiment Videos

  • Selection analyses (dN/dS ratios) to identify positive and negative selection.
  • Functional divergence tests on Hox7 paralogs.

    • Main Results:

    • Variable selective pressures were identified acting on Hox7 genes across different evolutionary lineages.
    • Episodes of positive selection were detected following Hox7 gene duplication events.
    • Significant functional differentiation was observed in a key region modulating HOX7 protein activity among paralogs.

    Conclusions:

    • Both positive and negative selection on coding regions significantly influence Hox7 gene evolution.
    • Functional divergence in specific protein regions contributes to evolutionary innovation.
    • Understanding these evolutionary dynamics is key to deciphering vertebrate functional and morphological diversity.