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Pharmacological activity of phenazepam and flunitrazepam in ultralow doses
G M Molodavkin1, T A Voronina, L I Chernyavskaya
1Institute of Pharmacology, Russian Academy of Medical Sciences, Moscow.
Bulletin of Experimental Biology and Medicine
|September 2, 2003
Abstract:
Experiments on male outbred albino rats showed that benzodiazepine tranquilizers phenazepam and flunitrazepam in ultralow doses (10(-9)-10(-15) mol/kg) produced an anxiolytic effect in the conflict situation test. This effect was not accompanied by myorelaxing and sedative side effects typical of standard doses of tranquilizers.