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Natural autoantibodies as tools to predict the outcome of immune response?
H Kohler1, J Bayry, A Nicoletti
1Department of Microbiology and Immunology, University of Kentucky, Lexington, KY 40536, USA. hkohl00@pop.uky.edu
Scandinavian Journal of Immunology
|September 3, 2003
Abstract:
Natural autoantibodies (NAbs), produced by B-1 B-cells, are directed against autoantigens and pathogens. NAbs can capture and present antigen to T helper cells thereby initiating adaptive immunities. It is proposed that screening for NAbs against pathogens will predict the strength of an antigen-induced immune response and could be used as a tool for vaccine development.