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Ligand-free Heck reaction: Pd(OAc)2 as an active catalyst revisited
Qingwei Yao1, Elizabeth P Kinney, Zhi Yang
1Department of Chemistry and Biochemistry, The Michael Faraday Laboratories, Northern Illinois University, DeKalb, Illinois 60115-2862, USA. qyao@niu.edu
The Journal of Organic Chemistry
|September 13, 2003
Abstract:
Palladium acetate was shown to be an extremely active catalyst for the Heck reaction of aryl bromides. Both the base and the solvent were found to have a fundamental influence on the efficiency of the reaction, with K(3)PO(4) and N,N-dimethylacetamide being the optimal base and solvent, respectively.