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Related Experiment Videos

Use of risperidone in a paediatric population: an observational study.

B King1, K Zwi, K Nunn

  • 1Department of Psychological Medicine, The Children's Hospital at Westmead, Westmead, New South Wales, Australia.

Journal of Paediatrics and Child Health
|September 13, 2003
PubMed
Summary

Risperidone effectively improved behavior and function in children with severe disturbances, but side effects were common. Further trials are needed to confirm safety and efficacy.

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Area of Science:

  • Child and Adolescent Psychiatry
  • Pharmacology
  • Neuroscience

Background:

  • Severe behavioral disturbances in children and adolescents pose significant challenges.
  • Functional impairment is a key concern in pediatric behavioral disorders.

Purpose of the Study:

  • To assess the efficacy of risperidone in improving functional impairment in pediatric patients.
  • To document the adverse drug reactions associated with risperidone use in this population.

Main Methods:

  • Retrospective assessment of 51 children and adolescents treated with risperidone.
  • Evaluation of clinical response and adverse events.
  • Measurement of functional performance using the Measure of Function (MOF) score.

Main Results:

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  • 76% of patients showed clinical improvement after an average of 9 months.
  • A statistically significant improvement in mean MOF scores was observed.
  • Common side effects included sedation (27%) and weight gain (20%).

Conclusions:

  • Risperidone appears effective for severely behaviorally disturbed pediatric patients, particularly those with autistic spectrum disorders.
  • High frequency of side effects may limit risperidone's use.
  • Randomized controlled trials are necessary to establish definitive safety and efficacy.