Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Radiation-induced optic neuropathy.

G Sallet1, P Kestelyn

  • 1Department of Ophthalmology, University Hospital, Ghent, Belgium.

Bulletin De La Societe Belge D'Ophtalmologie
|January 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Identification of novel disease gene for primary congenital glaucoma (PCG) through homozygosity mapping and next-generation sequencing.

Bulletin de la Societe belge d'ophtalmologie·2011
Same author

Stability of differential susceptibility and infectivity epidemic models.

Journal of mathematical biology·2010
Same author

Contact lens-related Fusarium keratitis in London and Ghent.

Eye (London, England)·2008
Same author

Recreational use of 3,4-methylenedioxymethamphetamine ('ecstasy') relieving symptoms of posterior scleritis.

Eye (London, England)·2007
Same author

Refractive outcome after bilateral implantation of an apodized diffractive intraocular lens.

Bulletin de la Societe belge d'ophtalmologie·2006
Same author

Expression of chemokines and gelatinase B in sympathetic ophthalmia.

Eye (London, England)·2006
Same journal

Didactic image poppers maculopathy.

Bulletin de la Societe belge d'ophtalmologie·2014
Same journal

[Marcus Gunn Syndrome. Study of 3 rare cases].

Bulletin de la Societe belge d'ophtalmologie·2014
Same journal

[Ocular manifestations of children living with HIV/AIDS in Kinshasa].

Bulletin de la Societe belge d'ophtalmologie·2014
Same journal

[Management of rhegmatogenous retinal detachment with unseen breaks: about 50 cases].

Bulletin de la Societe belge d'ophtalmologie·2014
Same journal

Long term IOP lowering efficacy of bimatoprost/timolol fixed combination: a 12 month prospective study.

Bulletin de la Societe belge d'ophtalmologie·2014
Same journal

[Palpebral pilomatricoma simulating a chalazion in a young adult].

Bulletin de la Societe belge d'ophtalmologie·2014
See all related articles

Radiation-induced optic neuropathy, a complication of cranial radiotherapy, often leads to poor visual prognosis. Magnetic Resonance Imaging (MRI) with Gadolinium-DTPA aids diagnosis, but outcomes remain guarded, especially with brain necrosis.

Area of Science:

  • Neurology
  • Oncology
  • Radiology

Background:

  • Cranial radiotherapy is a standard treatment for various brain tumors and other head and neck malignancies.
  • Radiation-induced optic neuropathy (RION) is a recognized, yet challenging, complication following this therapeutic modality.
  • Early diagnosis and understanding of prognostic factors are crucial for managing RION.

Observation:

  • This study details four cases of RION, with two diagnosed via Magnetic Resonance Imaging (MRI).
  • Enhanced signal intensity on MRI after Gadolinium-DTPA administration was observed in the optic nerves of affected patients.
  • A literature review of 47 additional cases was conducted to assess outcomes and associated factors.

Findings:

  • Visual acuity less than 1/10 was reported in 78% of affected eyes, indicating a severe visual impairment.

Related Experiment Videos

  • The presence of concurrent brain necrosis significantly worsened the prognosis, with a mortality rate of 62% in such cases.
  • MRI with Gadolinium-DTPA appears to be a valuable tool for diagnosing RION.

    • Implications:

    • Accurate diagnosis of RION using advanced imaging like MRI is essential for appropriate patient management.
    • The high rate of visual loss underscores the need for strategies to mitigate radiation damage to the optic nerve.
    • The association with brain necrosis highlights the systemic impact of radiation therapy and the critical need for careful treatment planning and monitoring.