[Marcus Gunn Syndrome. Study of 3 rare cases]

Area of Science:

• Ophthalmology
• Neurology
• Genetics

Background:

• Marcus Gunn Syndrome is a rare congenital condition characterized by jaw-winking synkinesis.
• It involves aberrant innervation between the trigeminal and oculomotor nerves.

Observation:

• Three cases of Marcus Gunn Syndrome were reported: two bilateral cases in young boys and one adult case with associated congenital fibrosis.
• The adult case presented with ipsilateral inferior rectus muscle fibrosis.

Findings:

• Bilateral Marcus Gunn Syndrome is rare, as is its occurrence in adults.
• The association with congenital fibrosis in the adult case provided insights into the syndrome's etiopathogenesis.
• A supra nuclear origin is hypothesized for Marcus Gunn Syndrome.

Implications:

• Understanding the varied presentations of Marcus Gunn Syndrome is crucial for diagnosis and management.
• Further research into the neurodevelopmental origins of synkinetic disorders is warranted.
• This case series highlights the importance of thorough ophthalmological examination in suspected congenital neurological anomalies.