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[Attempts at modification of the polyester vascular prosthesis].
D Paluch1, J Staniszewska-Kuś, R Rutowski
1Zakład Chirurgii Eksperymentalnej i Badania Biomateriałów, Katedra Chirugii Urazowej Akademii Medycznej, Wrocławiu.
Polimery W Medycynie
|January 1, 1992
Summary
Modifying polyester vascular prostheses with various treatments did not improve their biological properties. Some modifications even led to adverse tissue reactions, narrowing the prosthesis lumen.
Area of Science:
- Biomaterials Science
- Vascular Surgery
- Medical Device Engineering
Context:
- Polyester vascular prostheses are crucial in replacing damaged blood vessels.
- Surface modifications aim to enhance biocompatibility and clinical performance.
- Existing prostheses (DALLONR) serve as a baseline for comparison.
Purpose:
- To evaluate the impact of surface modifications on polyester vascular prostheses.
- To assess improvements in biological properties and tissue integration.
- To determine the efficacy of treatments like electrical charging, silicone, collagen, and chitosan coatings.
Summary:
- Several modifications were applied to polyester vascular prostheses, including electrical charging, silicone, collagen, and chitosan coatings.
- Laboratory and animal (piglet) studies assessed electrical conductivity, hemolytic, and toxic effects.
- Radiological and pathomorphological analyses evaluated tissue reactions and biological property improvements.
Impact:
- None of the tested modifications significantly improved the biological properties of the vascular prostheses.
- Some modifications resulted in increased tissue reactions, leading to lumen narrowing or closure.
- Minor improvements observed with methanol cleaning were insufficient to warrant technological changes.