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Polyclonal origin of rheumatoid synovial T-lymphocytes
W Hylton1, C Smith-Burchnell, B K Pelton
1MRC Clinical Research Centre, Harrow, Middlesex.
British Journal of Rheumatology
|January 1, 1992
Abstract:
Nineteen T-cell clones from seven patients with RA were obtained by cloning infiltrating lymphocytes from needle synovial biopsies. Southern blot analysis of the T-cell receptor (TCR) beta-chain genes in these clones revealed that there were no T-cell clones with an identical rearrangement of the TCR beta gene. These results do not support the idea that the infiltrating T-lymphocytes in RA are of monoclonal or oligoclonal origin.