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Anticardiolipin antibody in stroke.

P Y Wang1, T M Leu, S J Tsai

  • 1Department of Internal Medicine, Taichung Veterans General Hospital, Taiwan, R.O.C.

Zhonghua Yi Xue Za Zhi = Chinese Medical Journal; Free China Ed
|February 1, 1992
PubMed
Summary

Anticardiolipin antibody (ACA) screening in stroke patients showed a low prevalence of 2%. This study found no strong association between ACA and stroke, questioning the value of routine ACA testing for stroke patients.

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Area of Science:

  • Neurology
  • Immunology
  • Vascular Medicine

Background:

  • Anticardiolipin antibody (ACA) is linked to cerebral ischemia and thrombosis.
  • The prevalence and significance of ACA in stroke patients remain unclear.
  • ACA is considered a marker for increased thrombotic risk.

Purpose of the Study:

  • To determine the prevalence of ACA in patients diagnosed with stroke.
  • To investigate the association between ACA and stroke, including infarction and hemorrhage.
  • To evaluate the clinical utility of routine ACA screening in stroke patients.

Main Methods:

  • Consecutive stroke patients admitted to the hospital were studied.
  • A total of 246 patients (141 men, 105 women) aged 34-91 years were screened for ACA.
  • ACA levels were measured, and positivity was assessed based on elevated concentrations, with isotype analysis performed.

Main Results:

  • Elevated ACA was found in 2% of stroke patients (2.3% with infarction, 1.3% with hemorrhage).
  • All positive cases involved IgG isotype ACA.
  • No significant association was identified between ACA positivity and stroke occurrence in this cohort.

Conclusions:

  • The prevalence of anticardiolipin antibody in stroke patients is low.
  • Routine screening for ACA in stroke patients is of questionable clinical value.
  • Further research may be needed to clarify the specific role of ACA in certain stroke subtypes.

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