Hydrogen peroxide-induced DNA damages in vitro revealed by electron microscopy

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S Chaudhuri1, N P Bhattacharyya, S B Bhattacharjee

  • 1Crystallography and Molecular Biology Division, Saha Institute of Nuclear Physics, Calcutta, India.

Journal of Electron Microscopy
|February 1, 1992
PubMed

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Overview of DNA Repair02:25

Overview of DNA Repair

In order to be passed through generations, genomic DNA must be undamaged and error-free. However, every day, DNA in a cell undergoes several thousand to a million damaging events by natural causes and external factors. Ionizing radiation such as UV rays, free radicals produced during cellular respiration, and hydrolytic damage from metabolic reactions can alter the structure of DNA. Damages caused include single-base alteration, base dimerization, chain breaks, and cross-linkage.
Chemically...