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Reactions of copper complexes with oxygen radicals generated by human neutrophils
R F Haseloff1, S Gruner, G G Wischnewsky
1Research Institute of Molecular Pharmacology, Berlin, FRG.
Journal of Bioluminescence and Chemiluminescence
|July 1, 1992
Abstract:
The intensity of the chemiluminescence of unstimulated human neutrophils in the presence of luminol was used to investigate the effects of low-molecular-weight copper complexes at the cellular level. In different models (superoxide dismutase mimetic activity, inhibition of haematoporphyrin derivative/light-induced lysis of cells), the biological activity of the complexes exceeded the activity of the ligands alone.