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Extramammary Paget's disease: diagnosis and disease pattern
1Department of Dermatology, School of Medicine, Stanford University, California.
Cutis
|September 1, 1992
Summary
Extramammary Paget's disease, a rare skin condition, often affects elderly women's perineum. Diagnosis can be confirmed using immunoreactants targeting apocrine glands, suggesting this is the disease's origin.
Area of Science:
- Dermatology
- Pathology
- Oncology
Background:
- Extramammary Paget's disease (EMPD) is a rare disorder affecting the skin.
- EMPD typically presents as lesions on the perineum in elderly women.
- Malignant proliferation is not consistently observed in all cases.
Purpose of the Study:
- To report clinical and histochemical features of five EMPD cases.
- To explore the association of EMPD with apocrine glands.
- To highlight diagnostic methods for EMPD.
Main Methods:
- Clinical case reporting.
- Histochemical analysis of lesions.
- Immunoreactant staining for apocrine gland identification.
Main Results:
- All five cases involved perineal lesions in elderly women.
- No invasive malignant proliferation was found in the dermis.
- Immunoreactants confirmed the link between EMPD and apocrine glands.
Conclusions:
- EMPD in these cases was confined to the epidermis.
- The findings support the hypothesis that EMPD originates from apocrine glands.
- Immunoreactants are valuable tools for diagnosing EMPD.