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Human papillomavirus infections.

A B Moscicki1

  • 1University of California, School of Medicine, San Francisco.

Advances in Pediatrics
|January 1, 1992
PubMed
Summary

Human papillomavirus (HPV) infections are linked to anogenital cancers. Research is evolving to refine diagnosis and treatment, aiming for conservative approaches for most HPV-induced diseases while aggressively treating high-grade neoplastic disease.

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Area of Science:

  • Oncology
  • Virology
  • Gynecologic Oncology

Background:

  • Human papillomavirus (HPV) infections have been historically recognized but their clinical diversity, morbidity, and mortality are understood within the last two decades.
  • Limited research was initially hampered by a lack of interest and in vitro culture systems.

Purpose of the Study:

  • To highlight the significant role of HPV in the development of anogenital cancers.
  • To discuss the implications of the HPV-anogenital cancer association on treatment guidelines and potential overdiagnosis.
  • To outline principles for diagnosis and treatment of HPV-related conditions.

Main Methods:

  • Review of molecular diagnostic techniques and their role in establishing HPV's link to cancer.
  • Emphasis on diagnostic evaluation including colposcopy and histologic confirmation.
  • Discussion of treatment strategies based on disease severity.

Main Results:

  • Strong evidence links HPV to cervical, vaginal, vulvar, penile, and anal cancers.
  • Conservative management, often observation, is recommended for the majority of HPV-induced diseases.
  • High-grade neoplastic disease requires aggressive treatment.

Conclusions:

  • HPV plays a critical role in anogenital cancers, necessitating refined diagnostic and treatment strategies.
  • Future research may lead to more appropriate treatment options, potentially reducing overdiagnosis and overtreatment.
  • Accurate diagnosis via colposcopy and histology is crucial, with treatment tailored to disease severity.

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