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On the role of bradykinin in secretion from vascular endothelial cells
1Gaubius Laboratory IVVO-TNO, Leiden, The Netherlands.
Agents and Actions. Supplements
|January 1, 1992
Abstract:
Bradykinin will induce, in perfused rat hindlegs, the acute release from endothelial cells of tissue-type plasminogen activator and of von Willebrand factor. This release is mediated by B2-receptors, requires the influx of extracellular calcium, and is modulated by cyclic nucleotides. A possible role of bradykinin in the physiological regulation of plasma levels of tissue-type plasminogen activator is discussed.