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[Patients with panic disorder: a 5-year follow-up study].

C A León1, W Arévalo, L F Gaviria

  • 1Departamento de Psiquiatría, Facultad de Salud, Universidad del Valle, Cali, Colombia.

Acta Psiquiatrica Y Psicologica De America Latina
|December 1, 1992
PubMed
Summary

This study followed 48 panic disorder patients treated with Alprazolam, Imipramine, or placebo 5 years prior. It assessed long-term outcomes, treatment effectiveness, and symptom evolution post-trial.

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Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Pharmacology

Background:

  • Panic disorder is a significant psychiatric condition requiring effective long-term management.
  • Previous short-term trials have established the efficacy of certain medications, but long-term outcomes require further investigation.
  • Understanding the sustained impact of initial treatments is crucial for guiding clinical practice.

Purpose of the Study:

  • To assess the long-term clinical course and evolution of panic disorder in patients treated in a previous 8-week trial.
  • To evaluate the effectiveness of initial treatments (Alprazolam, Imipramine, placebo) over a 5-year period.
  • To examine subsequent treatment choices and identify differences among patients based on their original medication group.

Main Methods:

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  • A 5-year follow-up of 48 outpatients diagnosed with panic disorder.
  • Analysis of clinical evolution, remission rates, and symptom persistence.
  • Assessment of initial treatment efficacy and subsequent treatment patterns.

    • Main Results:

    • Long-term outcomes and clinical evolution of panic disorder were evaluated.
    • Effectiveness of Alprazolam, Imipramine, and placebo from the original trial was assessed over 5 years.
    • Differences in outcomes were analyzed based on the initial treatment received.

    Conclusions:

    • The study provides insights into the long-term trajectory of panic disorder following short-term treatment.
    • Findings contribute to understanding the sustained effects of Alprazolam and Imipramine compared to placebo.
    • This research informs clinical decision-making regarding the long-term management of panic disorder.