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[Hypophyseal pseudomacroadenoma in primary hypothyroidism--2 case reports]
E Stokić1, T Ivković-Lazar, L Lepsanović
1Klinika za endokrinologiju, Institut za interne bolesti, Medicinski fakultet, Novi Sad.
Medicinski Pregled
|January 1, 1992
Summary
Primary hypothyroidism can cause hyperprolactinemia, potentially leading to pituitary tumors. This study explores the rare simultaneous occurrence of hypothyroidism and prolactin-secreting pituitary adenomas in two female patients.
Area of Science:
- Endocrinology
- Oncology
Background:
- Primary hypothyroidism is frequently associated with hyperprolactinemia.
- Prolonged untreated hypothyroidism may lead to thyrotropic cell adenomas.
- Rarely, primary hypothyroidism can coexist with pituitary prolactin adenomas.
Observation:
- Two female patients presented with primary hypothyroidism and pituitary pseudomacroadenomas.
- Substitutional therapy aimed to achieve euthyroid status.
- Persistent hyperprolactinemia and compressive signs post-euthyroid status were noted.
Findings:
- The clinical presentation suggests a potential coincidence of primary hypothyroidism and a pituitary prolactin tumor.
- Distinguishing between treatment-induced regression and coexisting adenoma is crucial.
- Persistent hyperprolactinemia despite euthyroid status indicates a likely coexisting prolactin adenoma.
Implications:
- This case highlights the importance of thorough evaluation in patients with hypothyroidism and hyperprolactinemia.
- Accurate diagnosis is essential for appropriate management of pituitary disorders.
- Understanding these complex interactions aids in refining treatment strategies for endocrine and pituitary diseases.