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Related Experiment Videos

[Dry eye as a therapeutic problem].

N Dimoski1, S Latinović, D Radnović

  • 1Klinika za ocne bolesti, Hajduk Veljkova, Medicinski fakultet, Novi Sad.

Medicinski Pregled
|January 1, 1992
PubMed
Summary
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Artificial tears like Hydroxypropyl methylcellulose (HPMC) did not increase tear secretion in dry eye syndrome patients. However, these treatments offered significant relief from subjective symptoms such as dryness and burning.

Area of Science:

  • Ophthalmology
  • Rheumatology
  • Pharmacology

Context:

  • Dry eye syndrome (DES) often co-occurs with systemic autoimmune diseases affecting connective tissues, such as Sjögren's syndrome and systemic lupus erythematosus.
  • Patients with DES and associated systemic conditions experience significant ocular discomfort, impacting their quality of life.
  • Substitution therapy using artificial tears is a common management strategy for DES.

Purpose:

  • To evaluate the efficacy of three artificial tear preparations—Liquifilm sol, Hydroxypropyl methylcellulose 0.3% (HPMC), and Ocutal sol—in treating dry eye syndrome in patients with systemic connective tissue diseases.
  • To assess the impact of these artificial tears on both objective measures of lacrimal secretion (Schirmer's test) and subjective patient-reported symptoms.

Summary:

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  • A study involving 42 patients with DES associated with systemic connective tissue diseases investigated the effects of Liquifilm sol, HPMC 0.3%, and Ocutal sol.
  • One month of treatment with any of the artificial tear preparations did not lead to statistically significant improvements in Schirmer's test values, indicating no increase in lacrimal secretion.
  • Despite the lack of objective improvement in tear production, a majority of patients reported subjective relief from dry eye symptoms, including burning and dryness, with percentages ranging from 60% to 69% depending on the preparation used.

    • Impact:

    • This research suggests that while artificial tears may not restore tear function in DES patients with systemic conditions, they can effectively alleviate bothersome ocular surface symptoms.
    • The findings highlight the importance of considering subjective symptom relief as a primary treatment goal in managing dry eye associated with autoimmune diseases.
    • Further research could explore the mechanisms behind symptom improvement independent of lacrimal secretion changes and investigate long-term efficacy.