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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)
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Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus (MRSA)

Published on: February 9, 2011

Staphylococcic infections in children

R KOCH, G DONNELL

    California Medicine
    |November 1, 1957
    PubMed

    Insights

    Hospital-acquired staphylococcic infections are common and often resistant to penicillin and tetracycline. Chloramphenicol, bacitracin, novobiocin, and erythromycin are effective treatments, with better outcomes in older children.

    Area of Science:

    • Clinical Microbiology
    • Infectious Diseases
    • Pediatrics

    Background:

    • Hospital-acquired staphylococcic infections represent a significant clinical challenge.
    • High rates of antibiotic resistance, particularly to penicillin (92%) and tetracycline (74%), complicate treatment.
    • Staphylococcal infections pose a greater mortality risk to young infants (<2 months) compared to older children.

    Purpose of the Study:

    • To evaluate the prevalence and antibiotic resistance patterns of hospital-acquired staphylococcic infections.
    • To identify effective therapeutic antibiotic options and assess treatment correlation with sensitivity testing.
    • To determine the impact of age on mortality rates in staphylococcal infections.

    Main Methods:

    • Analysis of hospital-acquired staphylococcic infection cases.
    • Determination of antibiotic resistance profiles using the agar diffusion technique.
    • Correlation of clinical response with antibiotic therapy guided by sensitivity testing.

    Main Results:

    • Over 50% of staphylococcic infections were hospital-acquired, with high resistance to penicillin and tetracycline.
    • Chloramphenicol, bacitracin, novobiocin, and erythromycin demonstrated efficacy.
    • Mortality was significantly higher in infants under two months (7.8%) versus older children (1.1%), often due to pneumonia or septicemia.

    Conclusions:

    • Antibiotic sensitivity testing is crucial for effective management of hospital-acquired staphylococcic infections.
    • Chloramphenicol, bacitracin, novobiocin, and erythromycin are recommended therapeutic agents.
    • Vigilance and prompt treatment are essential for reducing mortality in vulnerable infant populations.
    Keywords:
    MICROCOCCAL INFECTIONS/in infant and child

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