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Related Experiment Videos

Multiple endocrine neoplasia type 2A.

H Shimizu1, Y Ueda, K Makino

  • 1Department of Internal Medicine, Chusei General Hospital, Suzuka, Japan.

Internal Medicine (Tokyo, Japan)
|June 1, 1992
PubMed
Summary

This case study highlights a patient with medullary thyroid carcinoma and bilateral pheochromocytomas. Further MIBG scintigraphy is planned to investigate persistent high hormone levels after surgery.

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Area of Science:

  • Endocrinology
  • Oncology
  • Surgical Pathology

Background:

  • A 40-year-old woman presented with symptoms suggestive of catecholamine excess.
  • A history of right hemithyroidectomy was noted, with prior specimen re-examination revealing medullary thyroid carcinoma.

Observation:

  • Bilateral adrenal tumors were identified via imaging (ultrasonography, CT, angiography).
  • Elevated serum catecholamine levels were confirmed in both adrenal veins.

Findings:

  • Histological examination confirmed bilateral pheochromocytomas.
  • Post-adrenalectomy, elevated serum calcitonin and urinary noradrenaline levels persisted.

Implications:

  • The case underscores the importance of investigating concurrent endocrine tumors in patients with medullary thyroid carcinoma.

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  • Further diagnostic evaluation, including 131I-metaiodobenzylguanidine (MIBG) scintigraphy, is warranted to assess residual or metastatic disease.