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Primary biliary cirrhosis in Israel
Israel Journal of Medical Sciences
|October 1, 1992
Summary
This study reports the first cases of primary biliary cirrhosis (PBC) in Israel
Area of Science:
- Hepatology
- Autoimmune Diseases
- Immunology
Background:
- Primary biliary cirrhosis (PBC) is a rare autoimmune liver disease.
- It involves the destruction of interlobular bile ducts.
- PBC has not been previously reported in the Middle East.
Purpose of the Study:
- To investigate the occurrence and characteristics of PBC in Israel.
- To determine if PBC is underdiagnosed in the region.
Main Methods:
- Retrospective analysis of 30 patients diagnosed with PBC at Hadassah Medical Center.
- Conventional diagnostic criteria, including serological markers (antimitochondrial and M2 antibodies, IgM levels) and liver biopsy.
- Biochemical parameters such as alkaline phosphatase, gamma-glutamyl transpeptidase, cholesterol, albumin, bilirubin, and prothrombin time were assessed.
Main Results:
- 30 patients (28 female, 2 male) diagnosed with PBC.
- Most patients were of Ashkenazic origin (22/30).
- Elevated liver enzymes, high IgM levels, and positive antimitochondrial/M2 antibodies were characteristic. Liver biopsy confirmed diagnosis in 27 patients.
Conclusions:
- This is the first report of primary biliary cirrhosis in the Jewish population in Israel.
- The findings suggest PBC may be underdiagnosed in Israel.
- Further research is needed to ascertain the true prevalence of PBC in the region.
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