Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Genetic variation in pathogenic bacteria.

B D Robertson1, T F Meyer

  • 1Max-Planck-Institut für Biologie, Abt. Infektionsbiologie, Tübingen, FRG.

Trends in Genetics : TIG
|December 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Precision-cut lung slices in air-liquid interface (PCLS-ALI): A novel <i>ex-vivo</i> model for the study of Pulmonary Aspergillosis.

bioRxiv : the preprint server for biology·2024
Same author

IFNγ-dependent silencing of TFF1 during <i>Helicobacter pylori</i> infection.

Open biology·2022
Same author

The Training of a Medical Officer.

Canadian Medical Association journal·2010
Same author

Correlation of T cell response and bacterial clearance in human volunteers challenged with Helicobacter pylori revealed by randomised controlled vaccination with Ty21a-based Salmonella vaccines.

Gut·2008
Same author

Helicobacter pylori infection in anterior uveitis.

Infection·2005
Same author

Impact of vector-priming on the immunogenicity of a live recombinant Salmonella enterica serovar typhi Ty21a vaccine expressing urease A and B from Helicobacter pylori in human volunteers.

Vaccine·2004
Same journal

Reading another hidden message in the genetic code.

Trends in genetics : TIG·2026
Same journal

The future of marsupial gene editing: What's in the (tool) pouch?

Trends in genetics : TIG·2026
Same journal

Genetic suppressors as new therapeutic targets for Mendelian diseases.

Trends in genetics : TIG·2026
Same journal

Beyond housekeeping: snRNA diversity, regulation, and human disease.

Trends in genetics : TIG·2026
Same journal

Rethinking mitochondrial metabolism: Intraindividual variability meets population constraints.

Trends in genetics : TIG·2026
Same journal

A role for epigenetics in rapid adaptation.

Trends in genetics : TIG·2026
See all related articles

Microbial genetic variation, not pure cultures, drives pathogen success and host resistance. This review explores the mechanisms and consequences of microbial genetic diversity in host-pathogen interactions.

Area of Science:

  • Microbiology
  • Genetics
  • Evolutionary Biology

Background:

  • Traditional microbiology often assumes pure cultures and defined strains.
  • However, genetic variation is a fundamental aspect of microbial life.
  • This variation plays a critical role in host-pathogen dynamics.

Purpose of the Study:

  • To review mechanisms driving microbial genetic variation.
  • To explore the functional consequences of this variation.
  • To highlight the importance of genetic diversity in microbial pathogenesis and host interaction.

Main Methods:

  • Literature review of studies on microbial genetic variation.
  • Analysis of mechanisms contributing to genetic diversity.
  • Synthesis of research on the functional impacts of variation.

Related Experiment Videos

Main Results:

  • Microbial genetic variation is pervasive and essential for adaptation.
  • Mechanisms include mutation, horizontal gene transfer, and recombination.
  • Variation enables pathogens to colonize hosts and evade immune responses.

Conclusions:

  • Genetic variation is a key factor in microbial pathogenesis.
  • Understanding these mechanisms is crucial for developing effective treatments against pathogens.
  • The dynamic nature of microbial genetics necessitates ongoing research.