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Noncontact optical tomography of turbid media
Ralf B Schulz1, Jorge Ripoll, Vasilis Ntziachristos
1Laboratory for Bio-optics and Molecular Imaging, Center for Molecular Imaging Research, Massachusetts General Hospital & Harvard Medical School, Building 149, 13th Street, Suite 5209, Charlestown, Massachusetts 02129, USA.
Abstract:
Optical tomography of turbid media has so far been limited by systems that require fixed geometries or measurements employing fibers. We present a system that records noncontact optical measurements from diffuse media of arbitrary shapes and retrieves the three-dimensional surface information of the diffuse medium. We further present a novel method of combining this composite data set and obtain accurate fluorescence reconstructions. This approach offers significant experimental simplicity and yields high-information-content datasets. The performance of this novel tomographic approach is demonstrated with experimental reconstructions of phantoms.