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Stabilisation of eudesmane cation by tryptophan 334 during aristolochene synthase catalysis
Athina Deligeorgopoulou1, Susan E Taylor, Silvia Forcat
1School of Chemical Sciences, University of Birmingham, Edgbaston, Birmingham, UK B15 2TT.
Chemical Communications (Cambridge, England)
|September 19, 2003
Abstract:
Analysis of the hydrocarbons produced during catalysis by mutants of aristolochene synthase from Penicillium roqueforti indicated that Trp 334 had a pivotal function for the efficient production of aristolochene from farnesylpyrophosphate most likely by stabilising the intermediate, eudesmane cation.