Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Regulating gene expression in transgenic animals.

C A Kappel1, S X Zhang, C J Bieberich

  • 1Laboratory of Virology, Jerome H. Holland Laboratory, Rockville, MD 20855.

Current Opinion in Biotechnology
|October 1, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

[Solid pseudopapillary tumor of the pancreas combined with serous cystadenoma: report of a case].

Zhonghua bing li xue za zhi = Chinese journal of pathology·2026
Same author

Diverse Properties of Electron Forbush Decreases Revealed by the Dark Matter Particle Explorer.

Physical review letters·2026
Same author

[Field epidemiology: core theories and subdisciplinary perspectives].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2025
Same author

[Field epidemiology: an evolutionary perspective and contemporary challenges].

Zhonghua liu xing bing xue za zhi = Zhonghua liuxingbingxue zazhi·2025
Same author

[Invasive <i>tracheobronchial aspergillosis</i> resulting in severe tracheal stenosis:a case report].

Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases·2025
Same author

[Sinicization and reliability and validity the European organization for research and treatment of cancer quality of life questionnaire-head and neck 43].

Zhonghua er bi yan hou tou jing wai ke za zhi = Chinese journal of otorhinolaryngology head and neck surgery·2025
Same journal

Microbial C1 assimilation pathways for chemical synthesis: from native metabolism to synthetic design.

Current opinion in biotechnology·2026
Same journal

Medicinal plants fermentation: current knowledge and perspectives.

Current opinion in biotechnology·2026
Same journal

Fermented foods: lessons learned from metagenomics.

Current opinion in biotechnology·2026
Same journal

Microfluidic platforms for the transient transfection of mammalian cells: recent developments and challenges.

Current opinion in biotechnology·2026
Same journal

Harvesting insights from recent advances in yeast genomics for predictable and precision wine fermentation.

Current opinion in biotechnology·2026
Same journal

Minimal enzyme cascades for the aromatic-to-aromatic upgrading of lignin monomers.

Current opinion in biotechnology·2026
See all related articles

Transgenic animals are essential for studying gene function and regulation. This review explores strategies for targeted gene expression and functional gene knockout in vivo research.

Area of Science:

  • Genetics and Molecular Biology
  • Animal Models
  • Gene Function Analysis

Background:

  • Mammalian gene isolation frequently outpaces functional characterization.
  • The human genome project will accelerate the discovery of genes with unknown functions.
  • Understanding gene function is crucial across various scientific disciplines.

Purpose of the Study:

  • To review strategies for targeted and regulated gene expression in transgenic animals.
  • To discuss methods for structural and functional gene ablation in vivo.
  • To highlight the importance of transgenic models for elucidating gene roles.

Main Methods:

  • Review of existing literature on transgenic animal technology.
  • Analysis of techniques for in vivo gene manipulation.

Related Experiment Videos

  • Discussion of gene targeting and knockout methodologies.

    • Main Results:

    • Detailed examination of strategies for controlling gene expression in transgenic organisms.
    • Exploration of approaches for disabling gene function (ablation).
    • Emphasis on the versatility of transgenic models for genetic studies.

    Conclusions:

    • Transgenic animal models provide powerful tools for investigating gene function and regulation.
    • Strategic approaches to gene expression and ablation are critical for effective in vivo studies.
    • Further development in transgenic techniques will enhance our understanding of complex biological systems.