Related Experiment Video
Updated: Jun 29, 2026
10:53
Preparation of Acute Brain Slices Using an Optimized N-Methyl-D-glucamine Protective Recovery Method
Published on: February 26, 2018
Substance in peripheral nerve which influences oxygen uptake.
Science (New York, N.Y.)
|May 26, 1961
Summary
A substance in rat sciatic nerves boosts respiration in fresh nerves. This nerve substance is essential for glucose utilization and increased oxygen uptake during electrical stimulation.
Area of Science:
- Neuroscience
- Biochemistry
Background:
- The rat sciatic nerve is a crucial component of the peripheral nervous system.
- Nerve respiration and glucose metabolism are fundamental physiological processes.
Purpose of the Study:
- To investigate a substance within the rat sciatic nerve that influences nerve respiration.
- To determine the role of this substance in glucose utilization and oxygen uptake during nerve stimulation.
Main Methods:
- Extraction of a substance from rat sciatic nerve.
- Incubation of fresh normal nerves with the extracted substance.
- Measurement of oxygen uptake and glucose utilization with and without electrical stimulation.
Main Results:
- A substance diffusing from rat sciatic nerve significantly increased the respiration rate of fresh nerves.
- Both glucose utilization and oxygen uptake, enhanced by electrical stimulation, were dependent on the presence of this substance.
- The substance's effect was observed with or without glucose in the medium.
Conclusions:
- The rat sciatic nerve contains a diffusible substance that enhances nerve respiration.
- This substance plays a critical role in mediating the metabolic responses of nerves to electrical stimulation, including glucose uptake and oxygen consumption.
More Related Videos
06:24Paired Cisterna Magna Nanoinjection and Laser Speckle Contrast Imaging Assay to Study Cerebral Blood Flow Regulation In Vivo
Published on: July 8, 2025
14:39Cholinergic Ligand–dependent Modulation of Oxidative Phosphorylation Coupling in Digitonin-permeabilized BE(2)-C Neuroblastoma Cells
Published on: April 28, 2026
Related Concept Videos
01:29Excitatory and Inhibitory Effects of Neurotransmitters
When an action potential reaches the presynaptic axon terminal, it releases neurotransmitters from the neuron into the synaptic cleft at a chemical synapse. The released neurotransmitter can be excitatory or inhibitory. The critical criteria commonly used to determine whether a molecule is a neurotransmitter at a chemical synapse are the molecule's presence in the presynaptic neuron. Second, its release is in response to strong presynaptic depolarization. And lastly, the presence of specific...
01:26Neurochemical Transmission: Sites of Drug Action
Neurochemical transmission, the conduction of electrical impulses between neurons mediated by neurotransmitters, plays a vital role in various physiological processes. Autonomic drugs exert their effects by modulating neurotransmission within the autonomic nervous system. For instance, drugs such as hemicholinium block the precursor uptake necessary for synthesizing acetylcholine, an essential autonomic neurotransmitter. Following synthesis, neurotransmitters are stored in vesicles. Metyrosine...
01:30Neurotransmitters
Neurotransmitters play a crucial role in the communication between neurons in the autonomic nervous system. Neurons in the autonomic nervous system can be cholinergic or adrenergic depending on the neurotransmitters synthesized. Cholinergic neurons use acetylcholine as their primary neurotransmitter. This includes all the preganglionic fibers of the sympathetic and pre- and postganglionic fibers of the parasympathetic nervous systems. In addition, neurons of the somatic nervous system also use...
01:31Chemical Factors Affecting Respiration Centers
Chemical factors such as changing CO2, O2, and H+ levels in arterial blood play a critical role in influencing respiration depth and rates. These variations are detected by chemoreceptors—specialized sensors located in two primary body areas. Central chemoreceptors are found throughout the brain stem, including the ventrolateral medulla, while peripheral chemoreceptors are located in the aortic arch and carotid arteries.
CO2 has a potent influence on respiration and is strictly regulated. Under...
CO2 has a potent influence on respiration and is strictly regulated. Under...
01:17Other Factors Affecting Respiration Centers
Breathing is primarily an involuntary activity regulated by the brainstem respiratory centers. However, it can also be consciously controlled, allowing us to hold our breath or take deeper breaths when needed. This voluntary control is facilitated by the cerebral motor cortex, which bypasses the medullary centers to stimulate the respiratory muscles directly.
However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical level,...
However, the ability to hold one's breath voluntarily is not limitless. When the CO2 concentration in the blood reaches a critical level,...
01:31Neurotransmitters
Neurotransmitters are essential chemical messengers within the nervous system, facilitating the communication between neurons. These chemical messengers, varying in function and effect, are critical for sustaining various aspects of neurological health and emotional well-being.