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Related Experiment Videos

Cell death in cranial neural crest development.

P Jeffs1, K Jaques, M Osmond

  • 1Department of Anatomy, University of Cambridge, UK.

Anatomy and Embryology
|January 1, 1992
PubMed
Summary
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Cell death in specific rhombomeres of the avian hindbrain creates gaps in neural crest migration. This localized cell death explains why certain rhombomeres fail to contribute to craniofacial development.

Area of Science:

  • Developmental Biology
  • Neuroscience
  • Craniofacial Development

Background:

  • The rhombencephalic neural crest is vital for craniofacial structure development.
  • Neural crest cells migrate from the dorsal hindbrain in a discontinuous pattern.

Purpose of the Study:

  • To investigate the role of cell death in the discontinuous migration of avian rhombencephalic neural crest.
  • To identify specific regions of cell death and their correlation with neural crest migration patterns.

Main Methods:

  • Utilized vital dye tracing to observe cell death patterns in the avian rhombencephalon.
  • Employed neural crest markers to assess migration in relation to cell death domains.

Main Results:

  • Observed discontinuous cell death in the dorsal midline of the rhombencephalon, beginning at stage 8.

Related Experiment Videos

  • Identified two distinct cell death domains by stage 11: one over rhombomeres RhA1/rh3 and another in the rh5 region.
  • Correlated these cell death domains with the absence of neural crest migration from rh3 and rh5.

    • Conclusions:

    • Segment-specific cell death in the dorsal rhombencephalon influences neural crest migration.
    • Localized cell death in particular rhombomeres may explain their failure to contribute to the cranial neural crest.