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Sex difference for tolerance of 5-HT1A receptor-mediated temperature and corticosterone responses in mice
Y Nakano1, T Matsuda, K Takuma
1Department of Pharmacology, Faculty of Pharmaceutical Sciences, Osaka, Japan.
European Journal of Pharmacology
|August 25, 1992
Abstract:
Repeated treatment with 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT) resulted in significant attenuation of 8-OH-DPAT-induced hypothermia and adrenocorticol effect in mice of both sexes, while it did not affect the 8-OH-DPAT-induced decrease in 5-hydroxyindoleacetic acid in the hypothalamus in either sex. The attenuated responses developed more rapidly in female than in male mice, indicating sex differences in the adaptive regulation of the 5-HT1A receptor-mediated responses.