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The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels
A W Schmidt1, S McLean, J Heym
1Department of Neuroscience, Pfizer Inc., Groton, CT 06340-1596.
European Journal of Pharmacology
|September 4, 1992
Abstract:
The nonpeptide substance P receptor antagonist CP-96,345 was found to displace binding to Ca2+ channel binding sites labelled with either [3H]desmethoxyverapamil or [3H]diltiazem and to enhance [3H]nitrendipine binding. Unlike the substance P receptor antagonist activity of CP-96,345, these effects on Ca2+ channel binding sites were neither stereoselective nor species-dependent. It is concluded that CP-96,345 may act as an antagonist of L-type Ca2+ channels in addition to being a potent NK1 receptor (substance P) antagonist.