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Related Experiment Videos

Photodynamic therapy.

U O Nseyo1

  • 1Department of Urology, West Virginia University Health Sciences Center, Morgantown.

The Urologic Clinics of North America
|August 1, 1992
PubMed
Summary
This summary is machine-generated.

Red-light whole-bladder photodynamic therapy shows promise for superficial bladder cancer treatment and prevention. This approach demonstrates high efficacy and safety, with no observed disease progression in high-risk patients.

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Area of Science:

  • Oncology
  • Photomedicine

Background:

  • Superficial bladder cancer presents a significant clinical challenge.
  • Current treatments for carcinoma in situ (Tis) and prophylaxis have limitations.

Purpose of the Study:

  • To evaluate the safety and efficacy of red-light whole-bladder photodynamic therapy (PDT) for Tis treatment.
  • To assess PDT's utility in the prophylactic management of superficial bladder cancer.
  • To explore PDT's potential for repeat treatments without increased resistance or morbidity.

Main Methods:

  • Preliminary data from phase II-III clinical trials involving red-light whole-bladder PDT.
  • Assessment of complete response rates and recurrence rates in patients with Tis.
  • Evaluation of recurrence rates and time to recurrence in patients undergoing prophylaxis.

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  • Monitoring for disease progression in stage or grade among high-risk patients.

    • Main Results:

    • Complete response rate of 88% in patients with Tis.
    • 25% recurrence rate in Tis patients over a mean follow-up of 20 months.
    • 31% recurrence rate in patients undergoing prophylaxis, with a median time to recurrence of 18 months.
    • No disease progression in stage or grade observed in high-risk patients treated with PDT.

    Conclusions:

    • Red-light whole-bladder PDT is a safe and effective option for Tis treatment.
    • PDT shows potential as a prophylactic measure for superficial bladder cancer.
    • Whole-bladder PDT offers advantages of high efficacy, potential for repeat treatment, and no increased tumor resistance or morbidity.