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Long-term effects of imipramine on striatal dopamine autoreceptor function: involvement of both noradrenergic and
C Scavone1, M L Aizenstein, C da S Planeta
1Departamento de Farmacologia, Universidade de São Paulo, Brazil.
General Pharmacology
|May 1, 1992
Abstract:
1. The effects of apomorphine (APO) administration on DA system activity were assessed by measuring dopamine metabolite levels (HVA) in several circumstances. 2. Pretreatment with IMI reduced the effect of APO on HVA levels. 3. Pretreatments with either IDE or DMI did not reduce the effect of APO on HVA levels. 4. Reductions of either NE and 5-HT levels after DSP4 and pCPA restored the effect of APO after IMI pretreatment.