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Studies on thyroid and hypophysary thyrotrophic hormone (TSH) in Down syndrome
Arquivos De Neuro-Psiquiatria
|March 1, 1977
Summary
Children with Down syndrome often have thyroid dysfunction. Studies show a slow thyroid response to thyroid-stimulating hormone (TSH) may be the primary issue in these patients.
Area of Science:
- Endocrinology
- Pediatrics
- Genetics
Background:
- Down syndrome is associated with an increased risk of thyroid dysfunction.
- Thyroid function abnormalities are common in children with Down syndrome.
Purpose of the Study:
- To investigate thyroid function in children with Down syndrome.
- To assess the response to thyroid-stimulating hormone (TSH) in this population.
Main Methods:
- Serum TSH levels were measured in 22 patients aged 4-15 years.
- Radioiodine uptake and clearance rates were assessed in 6 patients.
- TSH stimulation test (10 mIU-IM) was administered.
Main Results:
- 17 out of 22 patients had normal serum TSH levels.
- 5 patients exhibited elevated serum TSH.
- Thyroid uptake and clearance rates were generally below normal but showed a response to TSH stimulation.
Conclusions:
- Children with Down syndrome may exhibit a specific type of thyroid dysfunction.
- A delayed or blunted response to TSH appears to be a key characteristic.
- Further research is warranted to understand the underlying mechanisms.