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Decrease in bone level of 1,25-dihydroxyvitamin D in women over 45 years old.

P Sagiv1, C Lidor, T Hallel

  • 1Biochemistry Department, Weizmann Institute of Science, Rehovot, Israel.

Calcified Tissue International
|July 1, 1992
PubMed
Summary
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The active vitamin D metabolite, 1,25-dihydroxyvitamin D, showed no significant difference in serum levels across age or sex groups. Bone levels varied, with younger women exhibiting higher concentrations than older women.

Area of Science:

  • Endocrinology
  • Metabolic Bone Disease Research
  • Nutritional Biochemistry

Background:

  • 1,25-dihydroxyvitamin D [1,25(OH)2D] is the most active vitamin D metabolite.
  • Bone levels of 1,25(OH)2D may influence metabolic bone diseases like osteoporosis.

Purpose of the Study:

  • To investigate the role of bone 1,25(OH)2D in metabolic bone disease pathogenesis.
  • To determine the correlation between serum and bone 1,25(OH)2D levels.
  • To analyze 1,25(OH)2D levels by sex and age.

Main Methods:

  • Serum and bone samples were collected from 43 patients (18 men, 25 women) undergoing orthopedic surgery.
  • Patients were categorized into age groups: <45, 46-60, and >61 years.
  • 1,25(OH)2D levels were measured in serum and bone tissue.

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Main Results:

  • Mean serum 1,25(OH)2D levels were similar across all age and sex groups (30.7 +/- 2.18 pg/ml overall).
  • Mean bone 1,25(OH)2D levels were 29.4 +/- 2.81 pg/g overall, with no significant differences in men across age groups.
  • Younger women (<45 years) had significantly higher bone 1,25(OH)2D levels compared to older women (P < 0.005).

Conclusions:

  • Serum 1,25(OH)2D levels do not significantly correlate with age or sex in the studied population.
  • Bone 1,25(OH)2D levels show age-related differences in women, suggesting potential hormonal or metabolic influences.
  • Further research is needed to elucidate the role of bone 1,25(OH)2D in osteoporosis and its relationship with age and sex.