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Citrobacter sepsis in infants
R P Sugandhi1, V K Beena, P G Shivananda
1Department of Microbiology, Kasturba Medical College, Manipal.
Abstract:
A study of blood cultures from 320 cases of neonatal sepsis showed 136 (42.5%) to be positive for bacterial growth; of these 82 (60.29%) isolates being gram negative bacilli. Citrobacter was the commonest gram negative bacilli isolated. Other commonly isolated gram negative organisms were Pseudomonas, Klebsiella, Salmonella typhimurium, Acinetobacter and Escherichia coli. Antibiotics susceptibility pattern revealed the isolates to be resistant to commonly used antibiotics.
Insights
Neonatal sepsis blood cultures frequently showed bacterial growth, with gram-negative bacilli being the most common. These bacterial isolates exhibited resistance to frequently used antibiotics, posing treatment challenges.
Area of Science:
- Medical Microbiology
- Neonatal Infectious Diseases
- Antimicrobial Resistance
Background:
- Neonatal sepsis is a significant cause of infant mortality worldwide.
- Identifying causative pathogens and their antibiotic susceptibility is crucial for effective treatment.
Purpose of the Study:
- To investigate the bacterial pathogens causing neonatal sepsis in a specific cohort.
- To determine the antibiotic susceptibility patterns of isolated bacteria.
Main Methods:
- Blood cultures were collected from 320 neonates diagnosed with sepsis.
- Bacterial isolates were identified, and their susceptibility to various antibiotics was tested.
Main Results:
- Bacterial growth was detected in 136 (42.5%) of the blood cultures.
- Gram-negative bacilli constituted 82 (60.29%) of the positive isolates.
- Common gram-negative bacilli included Citrobacter, Pseudomonas, Klebsiella, Salmonella typhimurium, Acinetobacter, and Escherichia coli.
- A high degree of resistance to commonly used antibiotics was observed among the isolates.
Conclusions:
- Gram-negative bacilli are predominant pathogens in neonatal sepsis in this study population.
- The widespread antibiotic resistance among these isolates highlights a critical challenge for empirical therapy in neonatal sepsis.