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DISINFECTION OF AEROSOLIZED PATHOGENIC FUNGI ON LABORATORY SURFACES. I. TISSUE PHASE.

R H KRUSE, T D GREEN, R C CHAMBERS

    Applied Microbiology
    |September 1, 1963
    PubMed
    Summary

    Fungicides effectively eliminate pathogenic fungi like Blastomyces dermatitidis on lab surfaces. Surface type impacts efficacy, but concentration and time can be adjusted for disinfection.

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    Area of Science:

    • Mycology
    • Infectious Diseases
    • Laboratory Safety

    Background:

    • Pathogenic fungi pose risks in laboratory settings.
    • Effective decontamination protocols are crucial for preventing fungal transmission.

    Purpose of the Study:

    • To evaluate the efficacy of various fungicides against common pathogenic fungi.
    • To determine the influence of surface type on fungicidal activity.
    • To provide guidance for laboratory disinfection procedures.

    Main Methods:

    • Testing multiple fungicides against the tissue phase of Blastomyces dermatitidis, Coccidioides immitis, Cryptococcus neoformans, and Histoplasma capsulatum.
    • Statistical analysis correlating fungi, surfaces, time, and disinfectant concentration.
    • Assessing efficacy on various laboratory surfaces.
    Keywords:
    ANTIFUNGAL AGENTSBLASTOMYCESCOCCIDIOIDESCRYPTOCOCCUSEXPERIMENTAL LAB STUDYFUNGIHISTOPLASMALABORATORIESPHARMACOLOGYSTERILIZATION

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    Main Results:

    • All tested fungicides demonstrated effectiveness at specified concentrations and times.
    • The type of laboratory surface significantly influenced fungicidal efficacy.
    • Data allowed for interpolation to determine optimal disinfection parameters.

    Conclusions:

    • Fungicides are effective for decontaminating laboratory surfaces from pathogenic fungi.
    • Adjusting fungicide concentration and exposure time based on surface type is necessary for optimal disinfection.
    • This study provides a framework for safe laboratory practices when handling pathogenic fungi.